Osteoarthritis (OA) is a common cause of knee pain in older adults. OA is primarily caused by deterioration of
cartilage in the knee, which decreases the ability of synovial fluid to absorb shock and increases the opportunity for bones of
the joint to rub together. Hylan G-F 20 (Synvisc-One) is a compound that can be injected directly into the knee to help combat
the pain associated with OA by lubricating and cushioning the joint


Osteoarthritis (OA) affects more than 25 % of the adult population in the USA; it is most commonly associated with the elderly, but traumatic injury at any age can also be a cause [1]. OA is the most common degenerative joint disease and is characterized by progressive loss and destruction of articular cartilage, thickening of the subchondral bone, formation of osteophytes, inflammation of the synovium, degeneration of knee ligaments and hypertrophy of the knee capsule [2]. The primary symptoms of OA include chronic pain, joint instability and stiffness [3]. Treatment for OA consists of approaches to minimize the symptoms and includes: lifestyle changes (more exercise or changes in diet), pain relievers, physical or occupational therapy, steroid injections, viscosupplement injections and arthroplasty. Hylan G-F 20 (Synvisc-One; Sanofi Genzyme) is a viscosupplement gel mixture of hyaluronan. Significant quantities of hyaluronan naturally occur in the human joints, and act as lubricant and a shock absorber so the joint functions appropriately. The medication is injected directly into the patient’s knee to supplement the natural hyaluronan and is indicated for patients with OA who have not had sufficient pain relief from lifestyle changes, pain relievers or physical therapy. Side effects associated with Hylan G-F 20 injection include: pain, swelling, heat, redness, or fluid build-up in or around the knee. Hylan G-F 20can help reduce OA symptoms for up to 6 months [4]. We report here a unique infection following injection of Hylan G-F 20 in a 92-year-old patient with OA.



Categories : Microbiology

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